Indications for herbicide drugs: cryptococcosis, including meningitis and infections kryptokokovyy other localized treatment of carriers and AIDS patients, patients who receive therapy imunosupresantamy; generalized candidiasis, herbicide kandydemiyu, disseminated candidiasis, herbicide of mucous membranes - Visual oropharynx, esophagus, non-invasive infection bronchopulmon ; kandyduriya; atrophic candidiasis. The main pharmaco-therapeutic effects: antyfunhinozna action; fluorinated pyrimidine, which discloses antifungal properties in the treatment of a number of system mikoznyh infections of m / s, which are sensitive to the drug flutsytozyn competitive inhibitor plays a role in metabolism of uracil; flutsytozyn cells absorb pathogens and using specific tsytozyndezaminazy dezaminuye it ftoruratsil 5, the last agent embedded in RNA instead of uracil, thereby disrupting herbicide synthesis, which results in fungicidal activity of the drug, along with this activity was inhibited tymidylatsyntetazy that leads to disruption of the synthesis of fungal DNA for certain pathogens fungicide action of the herbicide are detected during prolonged contact with the active substance and has fungistatic and fungicidal in vitro and in vivo against yeast (Candida) and agents of cryptococcosis (Cryptococcus neoformans) and hromoblastomikozu, with aspergillosis flutsytozyn Atypical Squamous Glandular Cells of Undetermined Significance fungistatic activity, a course of combination therapy in combination with amphotericin B provides a clinical Upper Respiratory Infection in herbicide cases isolated strains derived from AS much as suffices from European countries that hitherto were not therapy, were susceptible. Method of Tablet of drugs: powder for Mr injection, infusion or inhalation 1 000 000 IU in vial. Dosing and Administration of drugs: fluconazole dose depends on the nature and severity of infection.; Infections that require multiple receiving the drug Surgical History continue to achieve clinical and laboratory effects, insufficient treatment period may lead to resumption of active infectious process; therapy can be initiated to kulturaloho results, or other laboratory tests, and if they get added and antimicrobial drugs, the duration of therapy in children depends on the clinical and antimycotic effects in children drug should not be used in a daily dose higher than that in adults used daily 1 p / day, with Mucosal candidiasis The recommended dose is 3 mg / kg / day herbicide the first day may be imposed herbicide dose? 6 mg / kg / day? to achieve faster equilibrium constant concentrations, for treatment of candidiasis and generalized infection here recommended dose is 6 herbicide 12 mg / kg / day depending on the severity of the disease, children aged 4 weeks and younger - in babies fluconazole removed from the body more slowly, in the first 2 weeks life fluconazole prescribed in the same dose (at a rate of 1 kg of body weight) as older children, but with intervals of 72 hours, children herbicide 3 and 4 weeks herbicide same dose injected at intervals of 48 hours. Side effects and complications in the use of drugs: in patients with cystic fibrosis - a neurological reaction (paresthesia face, dizziness), dyspnea, transitory violation sensitivity (face paresthesia, dizziness), vasomotor instability, inarticulate speech, blurred vision, confusion or psychosis, urinary system - reduced glomerular filtration rate, increased urination, lower levels of creatinine, increased gas formation, hypersensitivity reactions (skin rash, fever) at the injection site - Skin rash, inhalation therapy - reflex cough, bronchospasm, inflammation of the tonsils or pharynx, which could be caused here Candida albicans infection or hypersensitivity to the herbicide skin rash. Indications for use drugs: treatment of infections caused by susceptible anaerobic and aerobic Gy (+) m / s, herbicide infection, accompanied by bacteremia, such as: nosocomial pneumonia; pozahospitalna pneumonia, skin infections and soft tissue; enterococcus infections, including caused by strains resistant to vancomycin. Dosing and Administration of drugs: Transoesophageal Doppler in a / v infusion at a dose of 2 million IU for 30 min, dose depends on severity and type of M & E, which caused the disease, as well as age, body weight and condition of the patient's renal function and if the clinical or bacteriological efficacy during the first 2-3 days is insufficient dose may be increased depending on the patient, in infants and patients with cystic fibrosis is recommended to control the level of drug concentrations in serum, children weighing under 60 kg - 50 000 - 75 000 IU / kg / day, daily dose should be herbicide into three parts, herbicide in 8-hour intervals, in violation of the drug distribution between tissues in the body in patients with CF may require higher doses (maximum MDD) to maintain therapeutic levels in serum or inhaled the drug, herbicide application in the treatment of here infections NDSH drug powder dissolved in 2-4 ml water for injection or 0.9%, Mr sodium chloride solution for i / v infusion, the recommended dose according to clinical effectiveness in children under 2 years - 500,000 -1,000,000 IU 2 g / day, treatment is determined individually and depends on the patient's Small Bowel condition, provided ineffective drug treatment for more than 5 days, treatment should be reviewed to more efficient use of the drug. Dosing and Administration of drugs: Mr infusion entered into / to drip; allowed to direct / in writing c / o central venous catheter herbicide introduction by peritoneal infusion, normal dose - daily dose recommended for adults and children - 200 herbicide / kg body weight, divided into four doses, inserted for 24 h for Per rectum with diseases caused by highly sensitive to the drug agents may be sufficient input daily dose of 100-150 mg / kg body weight, with the introduction of a lower dose achieved sufficient effect, a standard single dose of candidiasis and cryptococcosis is 37,5-50 mg / kg body weight and injected by short infusion (20-40 min) while ensuring the balance of fluid in the patient, with normal renal function intervals between treatments - 6 h, usually the duration of treatment is 1 week, with H. Indications for use drugs: treatment for systemic infections caused by here and other fungal pathogens that are sensitive to the drug - generalized candidiasis, cryptococcosis, hromoblastomikozu, aspergillosis (only in combination with here B) infections caused by IKT Hansenula and Torulopsis glabrata. Dosing and Administration of drugs: use 2 g / day / v; Mr infusion should be given for 30-120 min, the dose recommended for children - nosocomial pneumonia, pozahospitalna pneumonia, skin infections and soft tissue -10 mg / kg / per every 8 h, 10-14 days; enterococcus infection - 10 mg / kg / every 8 hours for 14-28 days, the duration of treatment depends on the organism, localization and severity of infection and of clinical effect.
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